A weekly podcast for physicians interested in evidence based medicine and rheumatology. Find the papers at ebrheum.com
Episodes
Thursday Mar 14, 2024
Thursday Mar 14, 2024
Rheum4Debate is back!
In this episode I moderated a debate between two pulmonologists about RA-ILD. As a reminder, Rheum4Debate is an Oxford-style debate show, where two debators disagree over a motion during 3 rounds of discussion. The motion for todays show was:
“Asymptomatic patients with rheumatoid arthritis and high risk features for interstitial lung disease should be screened using pulmonary function testing and a high resolution CT scan”
Joshua defended the motion and Scott argued against it. I thoroughly enjoyed the discussion and am sure you will as well!
Monday Mar 11, 2024
Monday Mar 11, 2024
Nice study this week on an important topic. Can we prevent the development of rheumatoid arthritis by initiating DMARDs during a preclinical phase? Lots to discuss: what does it mean to be "pre-clinical?" How does this fit with other studies of this nature?
Check it out! https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)02650-8/fulltext
Monday Feb 26, 2024
Monday Feb 26, 2024
Informative podcast this week with Dr. Alexander Oldroyd, the first author of the recently published "International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening." The article itself appeared in Nature Reviews Rheumatology and provides what I think is a very useful framework for approaching this issue.
Article: https://www.nature.com/articles/s41584-023-01045-w
Monday Feb 05, 2024
Monday Feb 05, 2024
Quick methodology episode this week discussing the concept of "fragility" in randomized controlled trials of lupus. Really enjoyed discussing this paper and was grateful to have been a part of it. Get the text here: https://lupus.bmj.com/content/lupusscimed/11/1/e001068.full.pdf
Wednesday Jan 24, 2024
Wednesday Jan 24, 2024
Today I'm taking another twitter discussion into the podcast realm! Dr. Bhaskar Dasgupta has published hundreds of papers about polymyalgia rheumatica and giant cell arteritis, including a recent publication in Nature Reviews: Rheumatology that piqued my interest (https://www.nature.com/articles/s41584-023-00976-8).
In this podcast we discuss screening for GCA among patients with PMR, what it means to have a diagnosis, the role of novel IL-6 inhibitors, and many other topics. Have a listen and follow me @ebrheum and Dr. Dasgupta @profbdasgupta
Tuesday Jan 09, 2024
Tuesday Jan 09, 2024
Interesting topic and interesting paper this year, including discussion of observational biases, positive and negative controls, and interpreting data as it comes.
Paper: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2810259
Thursday Dec 14, 2023
Thursday Dec 14, 2023
Important trial on the podcast this week! I take a deep dive into the recently published SAPHYR study, which evaluated the use of the IL6 inhibitor sarilumab for patients with PMR. A few aggravating quibbles but overall a very useful trial and an important step forward for patients with PMR.
Article: https://www.nejm.org/doi/full/10.1056/NEJMoa2303452
Monday Oct 23, 2023
Monday Oct 23, 2023
This week I took a twitter disagreement from the impersonal world of twitter to the podcast world of a back and forth conversation. Really enjoyed talking to Dr. Len Calabrese about monoclonal antibodies, FDA regulatory pathways, and life in general.
Monday Oct 16, 2023
Monday Oct 16, 2023
Excited to share an editorial that I wrote along with Cody Bruggemeyer and Desh Nepal, two trainees with me at the Medical College of Wisconsin. We discussed what I believe to be a pervasive (but seldom discussed) issue in rheumatology RCTs: unblinding. I suspect many of our studies suffer from this. Have a listen!
Monday Oct 02, 2023
Monday Oct 02, 2023
Happy to share the FIRST randomized trial in CPPD today. It's kind of a weird study but worth a quick discussion.
https://www.sciencedirect.com/science/article/pii/S2665991323001650